abstract：:Most animals develop coelomic cavities lined by an epithelial cell layer called the mesothelium. Embryonic mesothelial cells have the ability to transform into mesenchymal cells which populate many developing organs contributing to their connective and vascular tissues, and also to organ-specific cell types. Furthermo...

journal_title：Seminars in cell & developmental biology

authors： Carmona R,Ariza L,Cano E,Jiménez-Navarro M,Muñoz-Chápuli R

更新日期：2019-08-01 00:00:00

abstract：:Can plants perceive sound? And what sounds are they likely to be "listening" to? The environment of plants includes many informative sounds, produced by biotic and abiotic sources. An ability to respond to these sounds could thus have a significant adaptive value for plants. We suggest the term phytoacoustics to descr...

journal_title：Seminars in cell & developmental biology

authors： Khait I,Obolski U,Yovel Y,Hadany L

更新日期：2019-08-01 00:00:00

abstract：:The pancreas is a compound gland comprised of both exocrine acinar and duct cells as well as endocrine islet cells. Most notable amongst the latter are the insulin-synthesizing β-cells, loss or dysfunction of which manifests in diabetes mellitus. All exocrine and endocrine cells derive from multipotent pancreatic prog...

journal_title：Seminars in cell & developmental biology

authors： Seymour PA,Serup P

更新日期：2019-08-01 00:00:00

abstract：:The intermediate mesoderm is located between the somites and the lateral plate mesoderm and gives rise to renal progenitors that contribute to the three mammalian kidney types (pronephros, mesonephros and metanephros). In this review, focusing largely on murine kidney development, we examine how the intermediate mesod...

journal_title：Seminars in cell & developmental biology

authors： Davidson AJ,Lewis P,Przepiorski A,Sander V

更新日期：2019-07-01 00:00:00

abstract：:Craniofacial muscles, muscles that move the eyes, control facial expression and allow food uptake and speech, have long been regarded as a variation on the general body muscle scheme. However, evidence has accumulated that the function of head muscles, their developmental anatomy and the underlying regulatory cascades...

journal_title：Seminars in cell & developmental biology

authors： Schubert FR,Singh AJ,Afoyalan O,Kioussi C,Dietrich S

更新日期：2019-07-01 00:00:00

abstract：:Multiple dimensions of genome organization play critical roles in the regulation of non-coding regions in gene expression in cell/organ development and pathogenesis. Precise measurements of multi-dimensional genome structure ensure data quality and fully depend upon the study design. We here overview the number of met...

journal_title：Seminars in cell & developmental biology

authors： Qian M,Cheng Y,Wang X

更新日期：2019-06-01 00:00:00

abstract：:The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular basement membrane (BM) and the interstitial ECM is identified as a crucial component of the vasculature. We here focus on the unique molecular composition and scaffolding of the capillary ECM, which provides structural support to b...

journal_title：Seminars in cell & developmental biology

authors： Marchand M,Monnot C,Muller L,Germain S

更新日期：2019-05-01 00:00:00

abstract：:Tumor progression and dissemination critically depend on support from the tumor microenvironment, the ensemble of cellular and acellular components surrounding and interacting with tumor cells. The extracellular matrix (ECM), the complex scaffolding of hundreds of proteins organizing cells in tissues, is a major compo...

journal_title：Seminars in cell & developmental biology

authors： Socovich AM,Naba A

更新日期：2019-05-01 00:00:00

abstract：:Fibrillin microfibrils are extensible polymers that endow connective tissues with long-range elasticity and have widespread distributions in both elastic and non-elastic tissues. They act as a template for elastin deposition during elastic fibre formation and are essential for maintaining the integrity of tissues such...

journal_title：Seminars in cell & developmental biology

authors： Thomson J,Singh M,Eckersley A,Cain SA,Sherratt MJ,Baldock C

更新日期：2019-05-01 00:00:00

abstract：:Canalization, or phenotypic robustness in the face of environmental and genetic perturbation, is an emergent property of living systems. Although this phenomenon has long been recognized, its molecular underpinnings have remained enigmatic until recently. Here, we review the contributions of the molecular chaperone Hs...

journal_title：Seminars in cell & developmental biology

authors： Zabinsky RA,Mason GA,Queitsch C,Jarosz DF

更新日期：2019-04-01 00:00:00

abstract：:The costs and benefits of random phenotypic heterogeneity in microbes have been vigorously debated and experimental tested for decades; yet, this conversation is largely independent from discussion of phenotypic robustness in other disciplines. In this review I connect microbial examples of stochasticity with studies ...

journal_title：Seminars in cell & developmental biology

authors： Draghi J

更新日期：2019-04-01 00:00:00

abstract：:The immune system plays an indispensable role in the process of tissue regeneration following damage as well as during homeostasis. Inflammation and immune cell recruitment are signs of early onset injury. At the wound site, immune cells not only help to clear debris but also secrete numerous signalling molecules that...

journal_title：Seminars in cell & developmental biology

authors： Abnave P,Ghigo E

更新日期：2019-03-01 00:00:00

abstract：:Freshwater planarians are well known for their remarkable plasticity and regenerative capabilities. Most studies of planarian regeneration have specifically examined regeneration after transverse or longitudinal sectioning or during homeostasis in intact adults. However, tissue transplantation, first performed over a ...

journal_title：Seminars in cell & developmental biology

authors： Rojo-Laguna JI,Garcia-Cabot S,Saló E

更新日期：2019-03-01 00:00:00

abstract：:Cell signaling is essential for cells to adequately respond to their environment. One of the most evolutionarily conserved signaling pathways is that of the epidermal growth factor receptor (EGFR). Transmembrane receptors with intracellular tyrosine kinase activity are activated by the binding of their corresponding l...

journal_title：Seminars in cell & developmental biology

authors： Barberán S,Cebrià F

更新日期：2019-03-01 00:00:00

abstract：:Most mammals cannot easily overcome degenerative disease or traumatic injuries. In contrast, an innate ability to regenerate is observed across animal phyla. Freshwater planarians are amongst the organisms that are capable of stem cell-mediated whole-body regeneration and have served as an exemplary model to study how...

journal_title：Seminars in cell & developmental biology

authors： Strand NS,Allen JM,Zayas RM

更新日期：2019-03-01 00:00:00

abstract：:Pigment cells serve a variety of important uses across the animal kingdom, and in many species can change and regenerate throughout the lifetime of the organism. The functions of these cells, as well as their origins in both embryonic development and adult regeneration, are not fully understood. Here, we review advanc...

journal_title：Seminars in cell & developmental biology

authors： Lindsay-Mosher N,Pearson BJ

更新日期：2019-03-01 00:00:00

abstract：:Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, ...

journal_title：Seminars in cell & developmental biology

authors： Alculumbre S,Raieli S,Hoffmann C,Chelbi R,Danlos FX,Soumelis V

更新日期：2019-02-01 00:00:00

abstract：:When entering tissues, monocytes can differentiate into cells that share morphological and functional features with either dendritic cells (DC) or macrophages. Monocyte-derived DC have been observed in humans at mucosal tissues and in inflammatory settings, where they are usually referred to as «inflammatory DC». In t...

journal_title：Seminars in cell & developmental biology

authors： Tang-Huau TL,Segura E

更新日期：2019-02-01 00:00:00

abstract：:Complement and dendritic cells (DCs) share many functional features that drive the outcome of immune-inflammatory processes. Both have a sentinel function, acting as danger sensors specialized for a rapid, comprehensive and selective action against potential threats without damaging the healthy host cells. But while c...

journal_title：Seminars in cell & developmental biology

authors： Luque A,Serrano I,Aran JM

更新日期：2019-01-01 00:00:00

abstract：:Motor neurons differentiate from progenitor cells and cluster as motor nuclei, settling next to the floor plate in the brain stem and spinal cord. Although precise positioning of motor neurons is critical for their functional input and output, the molecular mechanisms that guide motor neurons to their proper positions...

journal_title：Seminars in cell & developmental biology

authors： Kim M,Bjorke B,Mastick GS

更新日期：2019-01-01 00:00:00

abstract：:Lipids are now widely considered to play a variety of important roles in T-cell mediated immunity, including serving as antigens. Lipid-based antigens are presented by a specialised group of glycoproteins termed CD1. In humans, three classes of CD1 molecules exist: group 1 (CD1a, CD1b, CD1c), group 2 (CD1d), and group...

journal_title：Seminars in cell & developmental biology

authors： Le Nours J,Shahine A,Gras S

更新日期：2018-12-01 00:00:00

abstract：:Discovering how organisms and their proteins adapt to extreme conditions is a complicated process. Every condition has its own set of adaptations that make it uniquely stable in its environment. The purpose of our review is to discuss what is known in the extremophilic community about protein adaptations. To simplify ...

journal_title：Seminars in cell & developmental biology

authors： Brininger C,Spradlin S,Cobani L,Evilia C

更新日期：2018-12-01 00:00:00

abstract：:Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders. Most proteins are secreted using the conventional endoplasmic reticulum (ER)/Golgi network and as such, this pa...

journal_title：Seminars in cell & developmental biology

authors： Popa SJ,Stewart SE,Moreau K

更新日期：2018-11-01 00:00:00

abstract：:Although largely less numerous and characterized than bacterial secreted effectors, several viral virulence factors are secreted by virus infected cells. However, their mode of secretion only starts to be studied at the molecular level. Several of these viral effectors are secreted using an unconventional secretion pa...

journal_title：Seminars in cell & developmental biology

authors： Schatz M,Tong PBV,Beaumelle B

更新日期：2018-11-01 00:00:00

abstract：:The autophagy pathway known also as macroautophagy (herein referred to as autophagy) is characterized by the formation of double-membrane organelles that capture cytosolic material. Based on pathway termination alternatives, autophagy has been divided into degradative and secretory. During degradative autophagy, autop...

journal_title：Seminars in cell & developmental biology

authors： Claude-Taupin A,Bissa B,Jia J,Gu Y,Deretic V

更新日期：2018-11-01 00:00:00

abstract：:Both types of Drosophila egg chamber germ cells, i.e. oocyte and nurse cells, have to control their nucleus positions in order to produce a viable gamete. Interestingly, while actin microfilaments are crucial to position the nuclei in nurse cells, these are the microtubules that are important for oocyte nucleus to mig...

journal_title：Seminars in cell & developmental biology

authors： Bernard F,Lepesant JA,Guichet A

更新日期：2018-10-01 00:00:00

abstract：:Caspases are cysteine proteases that play important and well-defined roles in apoptosis and inflammation. Increasing evidence point to alternative functions of caspases where restricted and localized caspase activation within neurons allows for a variety of non-apoptotic and non-inflammatory processes required for bra...

journal_title：Seminars in cell & developmental biology

authors： Hollville E,Deshmukh M

更新日期：2018-10-01 00:00:00

abstract：:One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through d...

journal_title：Seminars in cell & developmental biology

authors： Lee YL,Burke B

更新日期：2018-10-01 00:00:00

abstract：:Skeletal muscle cells possess a unique cellular architecture designed to fulfill their contractile function. Muscle cells (also known as myofibers) result from the fusion of hundreds of myoblasts and grow into a fiber of several centimeters in length. Cellular structures gradually become organized during muscle develo...

journal_title：Seminars in cell & developmental biology

authors： Roman W,Gomes ER

更新日期：2018-10-01 00:00:00

abstract：:Low oxygen adaptation is essential for aerobic fungi that must survive in varied oxygen environments. Pathogenic fungi in particular must adapt to the low oxygen host tissue environment in order to cause infection. Maintenance of lipid homeostasis is especially important for cell growth and proliferation, and is a hig...

journal_title：Seminars in cell & developmental biology

authors： Burr R,Espenshade PJ

更新日期：2018-09-01 00:00:00

abstract：:The ability of cells to polarize is an intrinsic property of almost all cells and is required for the devlopment of most multicellular organisms. To develop cell polarity, cells integrate various signals derived from intrinsic as well as extrinsic sources. In the recent years, cell-cell adhesion receptors have turned ...

journal_title：Seminars in cell & developmental biology

authors： Ebnet K,Kummer D,Steinbacher T,Singh A,Nakayama M,Matis M

更新日期：2018-09-01 00:00:00

abstract：:Epithelial cell organization relies on a set of proteins that interact in an intricate way and which are called polarity complexes. These complexes are involved in the determination of the apico-basal axis and in the positioning and stability of the cell-cell junctions called adherens junctions at the apico-lateral bo...

journal_title：Seminars in cell & developmental biology

authors： Bazellières E,Aksenova V,Barthélémy-Requin M,Massey-Harroche D,Le Bivic A

更新日期：2018-09-01 00:00:00

abstract：:While the mutational activation of oncogenes drives tumor initiation and growth by promoting cellular transformation and proliferation, increasing evidence suggests that the subsequent re-engagement of largely dormant developmental pathways contributes to cellular phenotypes associated with the malignancy of solid tum...

journal_title：Seminars in cell & developmental biology

authors： VanderVorst K,Hatakeyama J,Berg A,Lee H,Carraway KL 3rd

更新日期：2018-09-01 00:00:00

abstract：:The tight control of reactive oxygen species (ROS) levels is required during regeneration. H2O2 in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H2O2 through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cel...

journal_title：Seminars in cell & developmental biology

authors： Meda F,Rampon C,Dupont E,Gauron C,Mourton A,Queguiner I,Thauvin M,Volovitch M,Joliot A,Vriz S

更新日期：2018-08-01 00:00:00

abstract：:Formation and maturation of a functional vascular network is a process called angiogenesis. This is a crucial biological event in all vertebrates. Precise morphogenetic and cellular mechanisms act in endothelial cells (ECs) to drive angiogenesis during growth and throughout adulthood. Reactive oxygen species (ROS) and...

journal_title：Seminars in cell & developmental biology

authors： Santoro MM

更新日期：2018-08-01 00:00:00

abstract：:Evidence emerges that redox gradients regulate morphogenesis, inflammation, regeneration, and healing of tissues. At the example of redox signaling during the zebrafish wound response, I briefly discuss current ideas on how such patterns might be sensed and spatially regulated to guide physiological processes over dis...

journal_title：Seminars in cell & developmental biology

authors： Niethammer P

更新日期：2018-08-01 00:00:00

abstract：:Mammalian genomes are pervasively transcribed, with long noncoding RNAs being the most abundant fraction. Recent studies have highlighted the central role played by these transcripts in several physiological and pathological processes. Despite several metabolic features shared between coding and noncoding transcripts,...

journal_title：Seminars in cell & developmental biology

authors： Samudyata,Castelo-Branco G,Bonetti A

更新日期：2018-07-01 00:00:00

abstract：:Mammalian spermatogenesis is a tightly coordinated process that gives rise to mature spermatozoa capable of fertilising an ovum during sexual reproduction. A population of stem and progenitor cells known as undifferentiated spermatogonia enables continual spermatogenesis throughout life. A complex transcriptional netw...

journal_title：Seminars in cell & developmental biology

authors： Legrand JMD,Hobbs RM

更新日期：2018-07-01 00:00:00

abstract：:Early life adversity remains a significant risk factor for the development of a host of negative behavioural and pathological outcomes in adulthood long after the stressor is over. Recent evidence indicates that these lasting effects of ELS may occur via alterations in the epigenetic landscape. Here, we review the mai...

journal_title：Seminars in cell & developmental biology

authors： Burns SB,Szyszkowicz JK,Luheshi GN,Lutz PE,Turecki G

更新日期：2018-05-01 00:00:00

abstract：:Perinatal environment plays a crucial role in brain development and determines its function through life. Epidemiological studies and clinical reports link perinatal exposure to infection and/or immune activation to various psychiatric disorders. In addition, accumulating evidence from animal models shows that perinat...

journal_title：Seminars in cell & developmental biology

authors： Depino AM

更新日期：2018-05-01 00:00:00